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John T. Myers, M.D.; A. D. Dunn, M.D.
JAMA. 1930;95(11):794-796. doi:10.1001/jama.1930.27210110001009a.
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Organisms commonly considered nonpathogenic may at times show definite disease-producing properties. However, they are rare experiences. Even Bacillus subtilis, a ubiquitous saprophyte, has been reported as the cause of panophthalmitis by Silberschmidt and others.1 Charrin and Nittis2 showed that B. subtilis acquired considerable pathogenic power by repeated transfers on blood agar. It has long been known that saprophytic molds may manifest pathogenic properties. Certain mucors, penicillium and aspergillus have been frequently reported. Harmer and Jackes3 reported Aspergillus fumugatus in pus from a maxillary sinus; MacFarlan,4 aspergillus niger from a tongue lesion; and Lynch,5 following bites of the red bug (leptus), or chigger. Panayotatou6 isolated a variety of penicillium which is usually harmless from a tongue lesion; the organism was definitely pathogenic for mice but not for rabbits. As might be anticipated, many cases of fungus infection have been reported in which the organism was


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