JAMA. 1926;86(12):820-822. doi:10.1001/jama.1926.02670380010006.
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Since the clinical scope and practical limitations of organotherapy will be ultimately defined only through the study of case histories as well as experiment protocols, there would seem to be justification for placing on record a case of dyspituitarism which has been under observation for twenty-eight months and in which the correlation between clinical status and the amount of thyroid extract ingested is well illustrated. The patient's imperfect cooperation during the earlier months of treatment has afforded a striking demonstration of the effects of both insufficient and excessive opotherapy.


History.  —W., a man, aged 35, seen, Dec. 11, 1922, gave a history of increasing drowsiness which had begun about three years before, and had become so marked that he would fall asleep during business conferences or while dictating letters. He had to be aroused once while answering questions relative to his medical history. There was obvious difficulty


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