THE SUPRARENAL CORTEX AND TUMOR

The possibility of a relationship between the suprarenal cortex and the growth of malignant neoplasms has recently become a prominent subject of inquiry. Sokoloff¹ has recorded the absorption of transplanted animal tumors after they had been injected with a preparation of cortex and an iron salt through which the gland was assumed to direct metabolism. Arloing, Josserand and Charachon² have described an inhibition of the growth of a mouse carcinoma after the subcutaneous introduction of suprarenal gland from a rabbit prepared by inoculations of the same tumor; they² found a glycerinated extract equally effective, whereas the normal gland proved to be inert, whether extracted or not. Activity was referred by these authors also to the cortex. Coffey and Humber,³ finally, have said that an extract of suprarenal cortex from the sheep causes sloughing and ultimate disappearance of malignant tumors in man, but they regarded their investigation