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Comment & Response |

Single-Gene Genotyping and Personalized Preventive Care

James A. Timmons, PhD1
[+] Author Affiliations
1King’s College London, London, England
JAMA. 2015;314(3):297-298. doi:10.1001/jama.2015.6218.
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To the Editor Dr Nan and colleagues1 demonstrated that the risk reduction for colorectal cancer afforded by regular use of aspirin (or other nonsteroidal anti-inflammatory drugs [NSAIDs]) was significantly associated with a single-nucleotide polymorphism (SNP) located on chromosome 12p12.3.

They concluded that validation in “additional populations may facilitate targeted colorectal cancer prevention strategies.” The accompanying Editorial2 goes further, citing the study as evidence that SNP (DNA analysis) testing can guide individualized prescription of long-term advice aimed at preventing disease. There are several caveats to these interpretations.


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July 21, 2015
Hongmei Nan, MD, PhD; Li Hsu, PhD; Andrew T. Chan, MD, MPH
1Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis
2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
3Division of Gastroenterology, Massachusetts General Hospital, Boston
JAMA. 2015;314(3):298. doi:10.1001/jama.2015.6233.
July 21, 2015
Richard C. Wender, MD
1American Cancer Society, Atlanta, Georgia
JAMA. 2015;314(3):298-299. doi:10.1001/jama.2015.6236.
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