Study concept and design: Pursnani, O’Donnell, Hoffmann.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Pursnani, O’Donnell, Hoffmann.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Pursnani, Massaro, D’Agostino.
Obtained funding: D’Agostino, O’Donnell, Hoffmann.
Administrative, technical, or material support: Hoffmann.
Study supervision: Pursnani, O’Donnell, Hoffmann.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Hoffmann reports receipt of grants from HeartFlow Inc, Siemens Healthcare, Genentech, and the American College of Radiology Imaging Network and personal fees from the American Heart Association. No other disclosures were reported.
Funding/Support: This work was supported by the National Heart, Lung, and Blood Institute’s Framingham Heart Study (contracts N01-HC-25195, HL076784, AG028321, HL070100, HL060040, HL080124, HL071039, HL077447, and HL107385). Dr Pursnani was supported by National Institutes of Health grant T32 HL076136.
Role of the Funder/Sponsor: The National Institutes of Health had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Correction: This article was corrected online on July 15, 2015, for clarification of a figure title.