Study concept and design: Levine, Galecki, Kabeto, Giordani, Wadley.
Acquisition, analysis, or interpretation of data: Levine, Langa, Unverzagt, Kabeto, Giordani, Wadley.
Drafting of the manuscript: Levine, Galecki, Giordani.
Critical revision of the manuscript for important intellectual content: Levine, Langa, Unverzagt, Kabeto, Giordani, Wadley.
Statistical analysis: Levine, Galecki, Kabeto.
Obtained funding: Levine.
Administrative, technical, or material support: Levine, Unverzagt, Kabeto, Giordani.
Study supervision: Levine, Galecki, Unverzagt, Giordani.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Levine reported receiving consulting fees from AstraZeneca and the National Institute of Neurological Disorders and Stroke for work on clinical trials; receiving a grant from the Michigan Alzheimer’s Disease Center; and serving as a member of the program advisory committee for the Kaiser Permanente Northern California (KPNC)–University of California, San Francisco (UCSF) Stroke Prevention/Intervention Research Program (SPIRP). No other authors reported disclosures.
Funding/Support: This work was supported by cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services. Additional funding was provided by a grant K23AG040278 from the National Institute on Aging (Dr Levine).
Role of the Funder/Sponsor: Representatives of the National Institute of Neurological Disorders and Stroke have been involved in the review of the manuscript but not directly involved in the collection, management, analysis, or interpretation of the data; or the decision to submit the manuscript for publication.
Disclaimer: The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Institutes of Health, or the Department of Veterans Affairs.
Additional Contributions: We thank the other investigators, the staff, and the participants of the REGARDS study for their valuable contributions. A full list of participating REGARDS investigators and institutions can be found at http://www.regardsstudy.org.