Study concept and design: Chau, Hopper, Jenkins, Win.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Dashti, Chau, Ouakrim, Winship, Jenkins, Win.
Critical revision of the manuscript for important intellectual content: Chau, Buchanan, Clendenning, Young, Winship, Arnold, Ahnen, Haile, Casey, Gallinger, Thibodeau, Lindor, Le Marchand, Newcomb, Potter, Baron, Hopper.
Statistical analysis: Dashti, Chau, Ouakrim, Jenkins, Win.
Obtained funding: Ahnen, Gallinger, Le Marchand, Newcomb, Potter, Hopper, Jenkins, Win.
Administrative, technical, or material support: Buchanan, Clendenning, Young, Thibodeau, Le Marchand, Newcomb, Hopper, Jenkins.
Study supervision: Winship, Ahnen, Hopper, Jenkins, Win.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Ahnen reports serving on the scientific advisory board for EXACT Sciences Inc and Cancer Prevention Pharmaceuticals. No other disclosures were reported.
Funding/Support: This work was supported by grant UM1 CA167551 from the National Cancer Institute, National Institutes of Health, and through cooperative agreements with members of the Colon Cancer Family Registry and principal investigators. Collaborating centers include the Australasian Colorectal Cancer Family Registry (U01/U24 CA097735), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794), Stanford Consortium Colorectal Cancer Family Registry (U01/U24 CA074799), and University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806). This work was also supported by Centre for Research Excellence grant APP1042021 and program grant APP1074383 from the National Health and Medical Research Council (NHMRC), Australia. Dr Win is an NHMRC Early Career Fellow. Dr Jenkins is an NHMRC Senior Research Fellow. Dr Hopper is an NHMRC Senior Principal Research Fellow. Dr Buchanan is a University of Melbourne Research at Melbourne Accelerator Program Senior Research Fellow.
Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content of this article does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government or the CFR.