JAMA. 1925;85(19):1490. doi:10.1001/jama.1925.02670190050018.
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Mann and Magath1 of the Mayo Foundation have demonstrated cogently that the maintenance of the normal level of sugar in the blood is absolutely dependent on the liver. The latter organ and its functioning are equally essential in the maintenance of a hyperglycemic blood sugar level, such as is observed in failure of the pancreatic activities on which the combustion of sugar in the blood seems to depend. It has been noted that the increase in blood sugar following pancreatectomy is dependent on the presence of the liver. Without an adequate amount of functioning liver tissue, the increase in blood sugar following removal of the pancreas does not occur. Thus it has been proved in another way that, whatever may be the process of carbohydrate metabolism, the liver has a vital part in that process. Distinction between the normal and the diabetic organism disappears when both liver and pancreas


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