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THE PATHOLOGY OF PEPTIC ULCER OF THE STOMACH

HOWARD T. KARSNER, M.D.
JAMA. 1925;85(18):1376-1380. doi:10.1001/jama.1925.02670180032008.
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This review will be confined to a consideration of the peptic ulcer, round ulcer or simple gastric ulcer, and will omit that interesting group of acute ulcers, all discussed by Schultze,1 which occur in acute infectious disease or which result from passive hyperemia with petechiae, from erosion by foreign bodies and other causes, and which tend to heal rapidly and leave no serious after-effects. The peptic ulcer is acute in its early stages but is peculiar in that it tends to persist and become chronic, heals slowly if at all, and may exhibit several dangerous complications and sequels.

GROSS MORBID ANATOMY  The peptic ulcer is usually a single, round or oval, sometimes distinctly elongated elliptic ulcer, situated in the posterior wall of the pyloric portion of the stomach near the lesser curvature. Except in the earliest stages, the ulcer is deep, may show a "punched out" appearance, may be

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