Edward B. Benedict, M.D.
JAMA. 1930;94(24):1916. doi:10.1001/jama.1930.27120500001011.
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In a previous communication, Lund and I1 reported a series of experiments in which it was shown that the depressing effect of morphine on the rate of metabolism was greater in rabbits after they had been thyroidectomized than before, and that morphine had almost no effect in the same rabbits when they had been rendered thyrotoxic by thyroid feeding. In other words, it appeared that the action of morphine is intensified by the hypothyroid state and diminished by the hyperthyroid state. These studies were undertaken because of an experience with a patient of Dr. F. B. Lund's, who, after receiving a routine dose of one-sixth grain (11 mg.) of morphine in preparation for laparotomy, went into coma and had a marked slowing of respiration which lasted for more than eight hours. The patient further gave a history of similar episodes on two prior occasions. On search for a cause


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