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William S. McCann, M.D.
JAMA. 1925;85(12):922. doi:10.1001/jama.1925.02670120060029.
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To the Editor:  —In the issue of September 12 appears a current comment on glycerol. The point is well taken, without doubt, especially since one Baltimore newspaper and a national press bureau widely heralded glycerin as a "cure" for diabetes about a year ago. Doubtless many patients took this newspaper authority as license to use glycerol ad libitum as an addition to the diet. Probably many physicians have likewise used glycerin without a full understanding of its relationship to carbohydrate metabolism.Beginning in 1922, with Dr. R. R. Hannon, I experimented with glycerol as a substitute for carbohydrate. It was known that glycerol was a sugar former and that it was antiketogenic. It seemed possible that to a certain extent glycerol could be oxidized as such, that is, without conversion into glucose, and that it might exert its antiketogenic effect without being so converted. Cremer had found that glycerol given


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