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JAMA. 1925;85(11):837-838. doi:10.1001/jama.1925.02670110051020.
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ABSTRACT

Treatment of Tuberculosis with the G. Dreyer Antigen  In May, 1923, G. Dreyer announced in a somewhat startling article that with the aid of a defatted tuberculous antigen he had been able to arrest in guinea-pigs the evolution of tuberculosis. It was with some surprise that the medical public learned, on reading the details of the announcement, that Dreyer's observations were confined to four guinea-pigs, which was a rather modest showing in view of the results claimed. In an attempt to confirm Dreyer's results, E. Grasset carried out experiments on a large number of animals in the laboratory of Professor Calmette at the Pasteur Institute. As is well known, the Dreyer antigen is obtained by treating with solution of formaldehyd tubercle bacilli, which are afterward defatted by acetone. After this treatment, the bacilli are no longer acid-resistant, and when emulsified in a 0.9 per cent. solution of sodium chlorid are

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