Ralph H. Major, M.D.
JAMA. 1923;81(23):1952. doi:10.1001/jama.1923.26510230002012a.
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The need of a satisfactory preservative in specimens of blood for chemical studies has long been felt in this clinic. This need has become greater with the increasing use of insulin.

Diabetic patients are often admitted to the hospital at hours when it is not possible to make estimations of the blood sugar and carbon dioxid, however desirable such examinations may be, and experience has shown us that specimens of blood collected in oxalate solution may be unsatisfactory for study the following day, even when kept on ice. The need of a preservative is also felt when the physician without adequate laboratory facilities wishes to mail a specimen of blood for determination of. the sugar and carbon dioxid tension.

We have been experimenting recently with various substances which are described as having an antiferment action and which should thus either delay or prevent the glycolytic activity of the blood. Some


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