In the course of an investigation 1 on the significance of an excess of uric acid in the blood in various dermatoses, we endeavored to determine whether it was possible to produce any disturbance of the skin in animals by the intravenous injection of large amounts of uric acid. Uric acid injections in man 2 had served only to illustrate, by its rapid elimination, the regulatory and protective power of the human organism. However, comparatively small amounts were injected and it was thought, in our work, that by using animals enormous quantities could be injected and some skin eruption might conceivably be evoked.
A 1 per cent, solution of uric acid in 0.44 per cent. lithium carbonate was used in all our experiments. The uric acid was determined by the method of Folin and Wu.3
A number of albino rats, each weighing 115 gm., were selected. The normal blood