JAMA. 1925;85(7):513-516. doi:10.1001/jama.1925.02670070033013.
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The frequency of unsuccessful operations on tumors of the hypophysis has led us to search for a method of approach that is less hazardous. Two fields seemed open—that of glandular therapy and that of radiotherapy.

The average benign enlargement of the pituitary gland will proceed along a certain stereotyped course. Ushered in by headaches, there will be a progressive enlargement of the gland, resulting in a constant pressure on the walls of the sella turcica. This fossa will enlarge according to the size of its contained tumor until symptoms of pressure on surrounding brain structures appear. Depending on the direction this growth takes, signs of pressure will develop. Associated with this there may or may not be signs of tissue changes or biochemical disorder, due to disturbance of the internal secretory mechanism of the pituitary or of a closely related gland.

The entire course tends toward recovery. Other endocrine glands


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