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THE TIME ELEMENT IN GALLSTONE FORMATION

ANGUS L. CAMERON, M.D., Ph.D.
JAMA. 1923;81(20):1671-1672. doi:10.1001/jama.1923.02650200021007.
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Although it is well known that small concretions can be produced experimentally in the gallbladder of laboratory animals within a period of a few days—ten days according to Klivert1—and that small deposits of bile elements may occur around suture material within a few weeks after its insertion into the human gallbladder, yet conclusive proof concerning the rapidity with which well developed calculi may form in the human gallbladder is lacking. Rolleston 2 quotes Mignot3 to the effect that it takes five or six months to form a stratified, well-formed biliary calculus. Moynihan4 cites a case reported by Rokitzski5 of a probably rapid formation of gallstones in a typhoid fever patient, aged 26, who was operated on at the end of the third week of her illness because of a suppurative cholecystitis. Fiftyeight apparently recently formed cholesterin calculi, showing a radiate arrangement, were removed. Cultures of

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