JAMA. 1925;84(20):1499. doi:10.1001/jama.1925.02660460035016.
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It was inevitable that when once the unique influence of insulin on carbohydrate metabolism was clearly established, investigators should be eager to discover the explanation of the phenomena involved. Probably the most striking manifestation of dosage with this hormone is the rapid decrease in the concentration of the blood sugar, which sets in so promptly that it early suggested some process occurring in the blood itself as responsible for the sugar-diminishing effect. Careful study of this has demonstrated conclusively that insulin does not influence the rate of glycolysis in blood; hence the hypoglycemia observed is not due to glycolysis. The liver, a storehouse of the sugar-forming glycogen, is not primarily concerned in the hypoglycemic action of insulin, for the characteristic effect of the latter continues even after exclusion of the hepatic tissues.1 Consequently, in the attempts to determine the seat of action of insulin, attention has been directed to


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