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Daniel N. Silverman, M.D.; Willey Denis, Ph.D.
JAMA. 1925;84(20):1495. doi:10.1001/jama.1925.26620460005012d.
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A rapid method for the determination of gastric acidity by means of test papers was recently described by us.1 Since this description, we have devised a compact indicator set2 for carrying out the method in clinical work.

The apparatus consists of a small wooden case which contains (a) six vials of standard buffer solutions ranging in pH from 3.0 to 1.4, each labeled respectively; (b) a vial of test papers impregnated with thymolsulphonephthalein solution, and (c) a vial of test papers impregnated with dimethylamino-azobenzene solution (Töpfer's reagent).

The hydrogen ion concentration of a sample of gastric contents is determined by pouring a small portion of the unfiltered material over one end of a test paper. From the table of colors in the accompanying tabulation it is then possible to tell at a glance whether the specimen is hyper, hypo, or of normal acidity. A small quantity of


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