Frank Smithies, M.D.; Richard Bartlett Oleson, M.D.
JAMA. 1925;84(20):1494-1495. doi:10.1001/jama.1925.26620460004012b.
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On the publication of Drs. Graham and Cole1 of their method of intravenous injection of the calcium salt of tetrabromphenolphthalein in order to develop a biliary tract opacity for roentgenographic observation, we tested the procedure and reported a series of cases.2 Our observations corroborated their findings. In our report we stated that we had seen no evidences of toxicity in the employment of the calcium salt and, indeed, our later practice would not cause us to alter this statement so far as the calcium salt is concerned. When, however, in accordance with the more recent suggestion of Graham and Cole,3 we used the sodium salt of tetrabromphenolphthalein, we encountered two patients who responded in so unsatisfactory a manner and caused us so much anxiety throughout their clinical courses that we have thought it advisable to report our experience.


Case 1.  —In the spring of


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