JAMA. 1925;84(17):1267-1268. doi:10.1001/jama.1925.02660430025011.
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Lately, it has been reported that mercurochrome-220 soluble fails to cure gonorrhea.1 Assuming that the drug was applied in a manner to obtain most efficient treatment, these failures might be accounted for on the basis that too numerous applications cause a tolerance

of the gonoccocus for the drug. In various reports of the treatment of gonorrhea, the main theme has been the alternate use of a dye and a silver preparation, that the most efficient treatment might be effected. Von Lackum and Hager 2 divide acute gonorrhea into arbitrary periods of seven to ten days, and in each of the first two periods use alternately a silver and a dye preparation. They state that in early chronic gonorrhea the patients "have already had too much treatment with protargin mild, and therefore do not respond well to its use. It is probable that here again a tolerance is developed on


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