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JAMA. 1923;81(3):202-203. doi:10.1001/jama.1923.02650030026010.
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Intracardiac injection of heart stimulants in acute cardiac failure had been tried many times without promising results until Dennis Crile1 of Chicago reported the use of massive doses of epinephrin chlorid. He introduced this both by direct puncture into the ventricle and by the intravenous route, showing beneficial results in all five cases reported, with recovery in two of them. Bodon2 has since reported ninety cases from the literature with permanent results in twentyfour, including one case of his own. In this series, a variety of stimulants were used, with no special emphasis on any single one. In Bodon's case, a patient with syphilitic coronary arteritis with acute cardiac failure, he used 1 c.c. of a 1: 1,000 epinephrin chlorid solution as a last resort after cessation of heart and respiration. A few seconds after this had been given by direct puncture into the ventricle, the heart began


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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