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V. P. Sydenstricker, M.D.
JAMA. 1923;81(2):113-114. doi:10.1001/jama.1923.26510020004010e.
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In 1904, Dresbach1 reported the case of a mulatto, aged 22, whose blood, otherwise normal, showed a striking morphologic change, in that 90 per cent. of the erythrocytes were oval or elliptic in outline. The width of the misshapen cells varied between 3.9 and 4.8 microns, the length between 8.5 and 10.7 microns. The patient was in perfect health at the time the observations were made. In 1914, Bishop2 reported a similar case in a white man, aged 41, who presented himself for treatment on account of acute appendicitis. Aside from the leukocytosis associated with acute inflammation, the blood presented no abnormality other than the presence of from 75 to 80 per cent. of oval and elliptic erythrocytes. Repeated examinations of the blood over a period of eight months showed no variation in the form of the red cells. The blood of one of this patient's sisters showed


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