Author Contributions: Drs Pokorney and Wang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Wang.
Acquisition, analysis, or interpretation of data: Pokorney, Miller, Chen, Thomas, Fonarow, de Lemos, Al-Khatib, Peterson, Wang.
Drafting of the manuscript: Pokorney, Chen, Thomas, Wang.
Critical revision of the manuscript for important intellectual content: Pokorney, Miller, Chen, Thomas, Fonarow, de Lemos, Al-Khatib, Peterson, Wang.
Statistical analysis: Chen, Thomas.
Obtained funding: Peterson, Wang.
Administrative, technical, or material support: Chen, Thomas, Wang.
Study supervision: Chen, Thomas, Peterson, Wang.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Pokorney reported having received grants or research support from AstraZeneca, Gilead, and Boston Scientific and having served on an advisory board for Janssen Pharmaceuticals. Dr Fonarow reported having served as a consultant or advisory board member for Ortho McNeil. Dr de Lemos reported having received honoraria from AstraZeneca and having served as a consultant or advisory board member for sanofi-aventis and Daiichi Sankyo. Dr Peterson reported having received grants or research support from Eli Lilly, Janssen Pharmaceuticals, and American Heart Association and having served as a consultant or advisory board member for Boehringer Ingelheim, Bristol-Myers Squibb, Janssen Pharmaceuticals, Pfizer, and Genentech. Dr Wang reported having received research grants or research support from Gilead, Eli Lilly, Daiichi Sankyo, AstraZeneca, Boston Scientific, Regeneron, and GlaxoSmithKline and having received honoraria from AstraZeneca and Eli Lilly. No other disclosures are reported.
Funding/Support: This project was supported by a grant from the Agency for Healthcare Research and Quality (U19HS021092). Additional support for this study was provided by an independent investigator-initiated research grant from Boston Scientific to the Duke Clinical Research Institute.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: Dr Peterson, an associate editor for JAMA, was not involved in the editorial review of or the decision to publish this article.