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Comment & Response |

Dosing Recommendations for New Oral Anticoagulants

Jörg Kreuzer, MD1; Klaus Dugi, MD1
[+] Author Affiliations
1Boehringer Ingelheim GmbH, Ingelheim, Germany
JAMA. 2015;313(24):2496. doi:10.1001/jama.2015.5739.
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To the Editor Dr Powell1 advocated for individualized therapy for the new direct-acting oral anticoagulants (DOACs) based on defined therapeutic target ranges simulated from phase 3 trials.

The idea of therapeutic drug monitoring is derived from the monitoring of vitamin K antagonists (VKAs), which have a narrow therapeutic window. Because of the multiple interactions of VKAs, therapeutic drug monitoring is the only possible way to ensure patient safety.


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June 23, 2015
J. Robert Powell, PharmD
1Eshelman School of Pharmacy, University of North Carolina, Chapel Hill
JAMA. 2015;313(24):2496-2497. doi:10.1001/jama.2015.5754.
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