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PANCREATIC SECRETION IN MAN

JAMA. 1923;80(16):1145-1146. doi:10.1001/jama.1923.02640430033017.
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The demonstration of the possibility of a chemical stimulation of the pancreatic gland to secretion, independently of the participation of secretory nerves, is justly regarded as a remarkable modern contribution to the science of physiology. The classic experiments which the London investigators Bayliss and Starling reported twenty years ago showed in a striking way that secretory glands can be excited to activity through influences which reach them by humoral as well as by nervous channels. Through the action of dilute acid on the duodenal mucosa, a substance, secretin, is formed which can accelerate the flow of pancreatic juice even when all nervous connections with the secretory gland are severed. The English physiologists early reached the conclusion that such a mechanism is involved normally in the production of pancreatic secretion, and is responsible for the flow obtained when acids find their way into the small intestine. Normally, this occurs at frequent

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