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SUPRARENAL CORTEX AND CANCER

Boris Sokoloff, M.D., Sc.D., Ph.D.
JAMA. 1930;94(9):652-653. doi:10.1001/jama.1930.02710350052024.
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ABSTRACT

To the Editor:  —In The Journal, February 1, there was a communication from Drs. Walter B. Coffey and John D. Humber concerning their method for the treatment of cancer by means of injections of extract of suprarenal cortex. They did not mention previous work relating to this question.Two years ago, while working at the Rockefeller Institute for Medical Research with Dr. Murphy on chicken sarcoma, I observed that the cortex of the suprarenal glands of chickens reacts intensively to the growth of this tumor. Dr. Sturm and I have shown that the weight of the suprarenal glands increases about five or six times in the chicken that is a bearer of the sarcoma.In a subsequent study of the suprarenal cortex of mice and rats inoculated with various types of malignant tumors, I observed that in these animals likewise a special reaction occurs in the X zone of the

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