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Comment & Response |

Varenicline for Smoking Reduction Prior to Cessation—Reply

Jon O. Ebbert, MD1; John R. Hughes, MD2; Robert J. West, PhD3
[+] Author Affiliations
1Mayo Clinic, Rochester, Minnesota
2Department of Psychiatry, University of Vermont, Burlington
3Health Behaviour Research Centre, University College London, London, England
JAMA. 2015;313(22):2285-2286. doi:10.1001/jama.2015.4981.
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In Reply Dr Cropsey and colleagues suggest that a carbon monoxide cutoff of 8 to 10 ppm or less may artificially inflate smoking abstinence rates and that a cutoff of 3 to 4 ppm or less may be more appropriate for determining abstinence in clinical trials in which smoking abstinence is the goal. For the current study, we used the recommendations of the expert panel convened by the Society for Research on Nicotine and Tobacco for the biochemical confirmation of abstinence.1


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June 9, 2015
Karen L. Cropsey, PsyD; C. Brendan Clark, PhD; Peter S. Hendricks, PhD
1Department of Psychiatry, University of Alabama, Birmingham
2School of Public Health, University of Alabama, Birmingham
JAMA. 2015;313(22):2284-2285. doi:10.1001/jama.2015.4972.
June 9, 2015
R. Brooks Robey, MD; Clay A. Block, MS, MD; Daniel J. O’Rourke, MS, MD
1Veterans Affairs Medical Center, White River Junction, Vermont
JAMA. 2015;313(22):2285. doi:10.1001/jama.2015.4978.
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