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Comment & Response |

Varenicline for Smoking Reduction Prior to Cessation

R. Brooks Robey, MD1; Clay A. Block, MS, MD1; Daniel J. O’Rourke, MS, MD1
[+] Author Affiliations
1Veterans Affairs Medical Center, White River Junction, Vermont
JAMA. 2015;313(22):2285. doi:10.1001/jama.2015.4978.
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To the Editor In a recent study,1 the partial nicotinic receptor agonist varenicline offered a viable cessation aid for smokers unwilling or unable to quit immediately but who were amenable to cigarette reduction prior to delayed attempts at full smoking cessation. Although the data from this randomized, double-blind, placebo-controlled multicenter study suggested benefit, marked heterogeneity in the study population was observed that warrants closer scrutiny to potentially identify specific subsets of patients who are the most or the least likely to benefit from such interventions.


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June 9, 2015
Jon O. Ebbert, MD; John R. Hughes, MD; Robert J. West, PhD
1Mayo Clinic, Rochester, Minnesota
2Department of Psychiatry, University of Vermont, Burlington
3Health Behaviour Research Centre, University College London, London, England
JAMA. 2015;313(22):2285-2286. doi:10.1001/jama.2015.4981.
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