JAMA. 1924;83(13):1002. doi:10.1001/jama.1924.02660130042015.
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The well marked pangs felt by a person who has been without food for some time, which are referred to the epigastric region, come and go at intervals. Physiologic investigation has demonstrated that they are associated with recurring strong contractions of the gastric musculature. These hunger pains and their antecedent gastric contractions are inhibited at times; occasionally, they are augmented with an increased tonus of the stomach. Starvation and muscular exercise, for example, have been demonstrated experimentally to increase the gastric hunger contractions. One of the symptoms accompanying the hypoglycemia induced in man by insulin is increased hunger. Such observations have suggested to Bulatao and Carlson 1 of the University of Chicago the possibility that the availability of carbohydrates for utilization by the stomach motor tissues may be an important factor in the genesis or intensity of the gastric hunger contractions. If their hypothesis is correct, experimental increase in the


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