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A. L. Benedict, M.D.
JAMA. 1922;79(24):2021-2022. doi:10.1001/jama.1922.02640240055030.
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To the Editor:  —Referring to your editorial comment on the alkaline tide in urine (The Journal, October 7, p. 1248), from studies that involved the saving and titration of urine for a month, from quite a number of fractional examinations covering periods of a day or more in patients, and from a few thousand single tests of urines: "there ain't no such thing."This crude and possibly rude contradiction should be qualified. It is quite possible that cryoscopic methods and definitions may show the alkaline and acid tides commonly taught for a century or more, and it may even be that the assumption of such a tide by so many of the early clinicians may not have been merely an induction from physiologic theory but that differences in diet may account for discrepant observations. Quite frequently, I have observed, not an alkaline tide but a diminution in gross acidity, following


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