JAMA. 1922;79(20):1654-1657. doi:10.1001/jama.1922.02640200004002.
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In this brief report, we wish to discuss some observations and conclusions based on a review of the literature and our personal experience with the prostatic cancer problem.

The literature is crowded with case reports, methods of treatment and statistics of results, but few have considered ways and means by which a larger percentage of these patients may be discovered early enough to give them permanent relief.

The incidence of cancer of the prostate to that of benign hypertrophy varies in reports from 15 to 25 per cent. The differentiation of cancer by our present methods of local examination is at times impossible, so that it is probably safe to estimate that at least one in four tumors of the prostate is malignant.

Fully one third of these patients give evidence of bone metastases at the time they seek relief, and many who do not show such evidence have extensive


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