JAMA. 1922;79(17):1428. doi:10.1001/jama.1922.02640170054018.
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Less than half a century has elapsed since the pregnant discovery, by von Mering and Minkowski in 1889, of the highly important part which the pancreatic gland plays in the control of carbohydrate metabolism in the body. Their classic experiments demonstrated that if the pancreas is completely extirpated, hyperglycemia, glycosuria, and the complete loss of the power to burn glucose or other carbohydrates ensue. There are many reasons for believing that lesions of the pancreas in man lead to disturbances in the metabolism of sugar such as manifest themselves clearly in the diabetic. Whether the determining lesions are confined to the islets of Langerhans in the pancreas, as some pathologic histologists assert, or whether other groups of pancreatic cells may be concerned in the genesis of diabetes, cannot be definitely stated at present. It has become customary to postulate an internal secretion for the islets, and to make this responsible


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