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PURIN SYNTHESIS IN MAN AND THE PRODUCTION OF URIC ACID

JAMA. 1922;79(11):898-899. doi:10.1001/jama.1922.02640110038013.
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The employment of purin-free diets in the therapy of certain conditions in man—a procedure widely advocated only a few years ago both in this country and in Europe—was based on the assumption that the precursors of uric acid are not formed de novo in adult man. As uric acid is the end-product of the metabolism of the ordinary dietary purins, whether they are ingested preformed or as constituent complexes of nucleoproteins, the regulation of the production and output of uric acid was naturally supposed to be controllable by restriction of the intake of its immediate antecedents. In harmony with this it is observed that, in contrast with the quantities of uric acid eliminated in the urine on a mixed diet, the output during a liberal purin-free regimen is almost always lowered.

Students of nutrition have found it necessary, however, to reckon with the further fact that, despite the exclusion of

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