0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

EFFECT OF REPEATED ADMINISTRATION OF ANESTHETICS ON BLOOD CATALASE

W. E. BURGE, Ph.D.
JAMA. 1922;79(7):545. doi:10.1001/jama.1922.02640070033010.
Text Size: A A A
Published online

ABSTRACT

We had already found that anesthetics produce a decrease in catalase, an enzyme possessing the property of liberating oxygen from hydrogen peroxid, and accordingly suggested that this decrease in catalase with resulting diminution in oxidation might be responsible for anesthesia. It was also found that a strong anesthetic, such as chloroform, produced a much greater decrease in catalase than a weaker anesthetic, such as ether, and that a rapidly acting anesthetic, such as nitrous oxid, decreased catalase more rapidly than a more slowly acting one.

The object of the present investigation was to determine the effect of repeated administrations of anesthetics on the blood catalase. The animals used were rabbits, and the anesthetics chloroform and ether. Catalase determinations were made by adding 1 c.c. of the rabbit's blood, diluted 1: 3 with 0.9 per cent. sodium chlorid, to neutral hydrogen peroxid, and the amount of oxygen liberated in ten minutes

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();