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JAMA. 1922;79(6):488. doi:10.1001/jama.1922.02640060070023.
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Bone Vascularization  Professor Lexer of Freiburg recently lectured at the Madrid Medical School on the vascularization of bones. He exhibited roentgenograms of bones in which he had previously injected mercury and other opaque materials. He was thus enabled to follow the formation of the vascular system in the bones of several mammals and of man at different ages, in health and in several pathologic conditions that involved the bone system. A feature in childhood is the marked vascularization of the metaphyses, which contributes to bone formation. As growth advances, this metaphyseal vascularization decreases, being replaced by an increase in the nutrient artery, which before was barely perceptible. This intense vascularization in the metaphyses explains the abundance of pathologic processes in them. Professor Lexer showed a femur amputated for synovial tuberculosis of the knee, in which the enlargements in the branches of the nutrient artery suggested an extravascular leakage of the


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