JAMA. 1922;79(2):136. doi:10.1001/jama.1922.02640020048016.
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The current conception of fever involves reactions which consist in an alteration of the body temperature, together with changes in the mechanism which controls this temperature. Fever can be induced by placing the body in an environment so warm and moist that heat cannot be lost by the usual devices of radiation, conduction and evaporation. In such a predicament there is an obvious failure of heat elimination. In persons suffering from ichthyosis hystrix involving an almost complete loss of function of the sweat glands,1 the body temperature can be varied by altering the temperature of the surroundings. Considerations such as these have been responsible for the view that a prominent factor in the genesis of fever is the failure of the mechanisms ordinarily responsible for the removal of heat from the body. On this hypothesis the increment of heat might be merely an exaggeration of that seen in healthy persons


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