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Comment & Response |

Treatment for Hospitalized Patients With Severe Community-Acquired Pneumonia—Reply

Antoni Torres, MD, PhD1
[+] Author Affiliations
1Hospital Clínic de Barcelona, Barcelona, Spain
JAMA. 2015;313(21):2184-2185. doi:10.1001/jama.2015.4777.
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In Reply Dr Pepper raises an interesting question related to the potential interaction between fluid balance and radiographic progression, mainly in patients with shock and severe sepsis. Unfortunately, we do not have data on fluid balance during the first 5 days after randomization.

Although we cannot specifically answer this question, our general practice was to keep patients in a negative or at least even fluid balance. Because the study was blinded and randomized, we do not think that changes in fluid balance accounted for differences in radiographic resolution.


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June 2, 2015
Dominique J. Pepper, MBChB, MD
1National Institutes of Health, Bethesda, Maryland
JAMA. 2015;313(21):2184. doi:10.1001/jama.2015.4774.
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