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Comment & Response |

Mortality and Ratio of Blood Products Used in Patients With Severe Trauma

Mohammad A. Helwani, MD, MSPH1; Jason R. Gillihan, MD1
[+] Author Affiliations
1Department of Anesthesiology, Washington University, St Louis, Missouri
JAMA. 2015;313(20):2078. doi:10.1001/jama.2015.4424.
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To the Editor In the PROPPR study,1 mortality was not statistically different between groups transfused with plasma, platelets, and RBCs in a 1:1:1 ratio compared with a 1:1:2 ratio. This lack of difference in mortality may be explained by the high rate of death related to traumatic brain injury (one-third of deaths), which could dilute the main effect of the transfusion intervention; and also by the large effect size that the study was trying to detect (10%).

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May 26, 2015
John B. Holcomb, MD; Erin E. Fox, PhD; Charles E. Wade, PhD; for the PROPPR Study Group
1Center for Translational Injury Research, University of Texas Health Science Center, Houston
JAMA. 2015;313(20):2078-2079. doi:10.1001/jama.2015.4427.
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