We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA |

Highlights FREE

JAMA. 2015;313(19):1883-1885. doi:10.1001/jama.2014.11749.
Text Size: A A A
Published online


In a randomized trial that enrolled 269 patients with acute radiculopathy due to a herniated lumbar disk, Goldberg and colleagues assessed the effect of a tapering 15-day course of oral prednisone (total cumulative dose, 600 mg) on physical function and pain. The authors report that compared with placebo, short-course oral steroids resulted in modest improvement in function but no improvement in pain.

Cerebral amyloid-β aggregation is an early neuropathological event in Alzheimer disease. In a meta-analysis of individual participant data from 55 studies (involving 2914 persons with normal cognition, 697 persons with subjective cognitive impairment, and 3972 persons with mild cognitive impairment), Jansen and colleagues estimated the prevalence of amyloid pathology from positron emission tomography imaging or cerebral spinal fluid findings. Among their findings was that the prevalence of cerebral amyloid pathology was associated with age, apolipoprotein E genotype, and the presence of cognitive impairment. In an Editorial, Rosenberg discusses the potential clinical use of amyloid imaging in the diagnosis of dementia and, perhaps, eventual treatment of persons at risk.

Related Article

Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of amyloid plaques—a key, but not defining, feature of Alzheimer disease. In an analysis of data from 1359 patients with Alzheimer disease, 538 patients with non–Alzheimer dementia, 1849 healthy controls, and an independent sample of 1359 patients with an autopsy diagnosis of Alzheimer disease, Ossenkoppele and colleagues found that the prevalence of amyloid positivity was associated with clinical diagnosis, age, and apolipoprotein E genotype—suggesting potential clinical utility of amyloid imaging in the diagnosis of some forms of dementia.

Editorial and Related Article


Atrial fibrillation is associated with a substantial increase in the risk of stroke. Based on a systematic review of studies relating to atrial fibrillation, stroke risk, and stroke prevention, Lip and Lane summarize current concepts and recent developments in stroke prevention for patients with atrial fibrillation. The authors review stroke and bleeding risk prediction scores and conclude that patients with atrial fibrillation and 1 or more stroke risk factor should be offered oral anticoagulant therapy.

An article in JAMA Neurology reported data from a prospective cohort study of middle-aged adults, which found that compared with normal blood pressure, midlife hypertension and elevated systolic blood pressure in midlife but not late life were associated with more cognitive decline during 20 years’ follow-up. In this From The JAMA Network article, DeCarli discusses the importance of early diagnosis and appropriate treatment of hypertension.

This JAMA Clinical Evidence Synopsis by Molyneaux and colleagues summarizes findings from an updated Cochrane review of antidepressants for postnatal depression. Based on the available evidence (6 studies; 596 patients), selective serotonin reuptake inhibitors are associated with higher rates of response and remission than placebo. Whether antidepressant medications have greater efficacy than psychological treatments and whether outcomes vary by depression severity could not be determined.

An 87-year-old woman with a history of open-angle glaucoma reported a gradual darkening of her right iris and right-side eyelash lengthening during the prior year, without changes in vision or foreign-body sensation. Her medications included bimatoprost, atenolol, atorvastatin, and clopidogrel. What would you do next?



Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.