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Comment & Response |

Hospitalization for Pneumonia and Risk of Cardiovascular Disease—Reply

Vicente F. Corrales-Medina, MD, MSc1; Karina N. Alvarez, MS2; Sachin Yende, MD, MS2
[+] Author Affiliations
1Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
2Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania
JAMA. 2015;313(17):1753-1754. doi:10.1001/jama.2015.3133.
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In Reply Dr Violi and colleagues raise the possibility that an association between hospitalization for pneumonia and subsequent increase in CVD risk may be confounded by differential use of aspirin prior to the occurrence of pneumonia. We did not include aspirin usage because it was missing in 11% to 40% of participants at various time points during the first 10 years of follow-up in the CHS. The Table shows aspirin use based on data collected at baseline and at additional time points prior to hospitalization for pneumonia if these data were available. Aspirin use was similar between the 2 groups, suggesting that confounding by unaccounted aspirin use is unlikely.

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May 5, 2015
Francesco Violi, MD; Roberto Cangemi, MD, PhD; Camilla Calvieri, MD
1Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy
2Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology, and Geriatric Sciences, Sapienza University of Rome, Rome, Italy
JAMA. 2015;313(17):1753. doi:10.1001/jama.2015.3130.
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