Study concept and design: Viatte, Plant, Thomson, Symmons, Worthington, Wilson, Raychaudhuri, Barton.
Acquisition, analysis, or interpretation of data: Viatte, Plant, Han, Fu, Yarwood, Symmons, Young, Hyrich, Morgan, Isaacs, Raychaudhuri, Barton.
Drafting of the manuscript: Viatte, Han, Fu, Wilson, Raychaudhuri, Barton.
Critical revision of the manuscript for important intellectual content: Viatte, Plant, Fu, Yarwood, Thomson, Symmons, Worthington, Young, Hyrich, Morgan, Isaacs, Raychaudhuri, Barton.
Statistical analysis: Viatte, Plant, Han, Fu, Yarwood, Hyrich, Raychaudhuri, Barton.
Obtained funding: Symmons, Worthington, Hyrich, Morgan, Raychaudhuri, Barton.
Administrative, technical, or material support: Thomson, Young, Morgan, Barton.
Study supervision: Thomson, Symmons, Worthington, Raychaudhuri, Barton.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Hyrich reported receiving speaker’s fees from Abbvie and honoraria from Pfizer. Dr Raychaudhuri reported receiving personal fees from Johnson & Johnson, Pfizer, and Novartis. Dr Barton reported receiving consultancy fees and grant support from Eli-Lilly, Pfizer, and Abbvie. No other disclosures were reported.
Funding/Support: This work was funded by core programme grant 20385 from Arthritis Research UK, by the National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, and by the Innovative Medicines Initiative Be The Cure (contract 115142-2). At the start of this project, Dr Viatte was supported by research grant PASMP3_134380 from the Swiss Foundation for Medical-Biological Scholarships, managed by the Swiss National Science Foundation. That grant is financed by a donation from Novartis to the Swiss Foundation for Medical-Biological Scholarships. Dr Raychaudhuri is supported by the Arthritis Foundation, the Doris Duke Foundation, and National Institutes of Health grants 1R01AR063759-01A1, 1R01AR062886-01, and 5U01GM092691.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the UK Department of Health.
Additional Contributions: We acknowledge the Early Rheumatoid Arthritis Study clinicians and research nurses: Josh J. Dixey (New Cross Hospital, Wolverhampton, England), C. Solymossy (St Albans City Hospital, St Albans, England), Paul Davies and Lynn Hill (Chelmsford, England), Jo Devlin, Paul Emery, and Lynn Waterhouse (Birmingham, England), Helen Tate (Grimsby, England), Cathy Boys (Basingstoke, England), Dora White (Medway, England), Helen Dart (Oswestry, England), Sue Stafford (Winchester, England), John Winfield (Sheffield, England), Annie Seymour (St Albans, England). Study coordinators and data managers: Cathy Mayes and Marie Hunt (St Albans, England). We also acknowledge the Norfolk Arthritis Register clinicians, research nurses, metrologists, and the database management team in Manchester, England, and the contributions of local general practitioners and rheumatologists in Norwich, England. We also acknowledge the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate members, clinicians (Kimme L. Hyrich, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, and Anne Barton), research nurses, patients, and the database management team in Manchester, England (also see appendix A of article by Plant et al23). We also acknowledge the assistance given by the University of Manchester IT Services and use of the Computational Shared Facility.