We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Viewpoint |

Neurotoxicity of Generic Anesthesia Agents in Infants and Children An Orphan Research Question in Search of a Sponsor

Bruce M. Psaty, MD, PhD1,2; Richard Platt, MD, MS3,4; Russ B. Altman, MD, PhD5,6
[+] Author Affiliations
1Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle
2Group Health Research Institute, Group Health Cooperative, Seattle, Washington
3Harvard Medical School, Boston, Massachusetts
4Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts
5Department of Bioengineering, Stanford University, Stanford, California
6Department of Genetics and Medicine, Stanford University, Stanford, California
JAMA. 2015;313(15):1515-1516. doi:10.1001/jama.2015.1149.
Text Size: A A A
Published online


This Viewpoint argues that more studies and trials are needed to address questions about the optimal dose, duration, and frequency of use of anesthetic agents and vulnerable periods of exposure in young children.

Millions of neonates and toddlers undergo anesthesia or sedation for surgeries and procedures each year. At the same time, mounting evidence from controlled studies in young animals suggests that anesthetic agents, administered during vulnerable periods, have neurotoxic effects that result in long-lasting deficits in learning and cognitive behavior. The relevance of these animal models to humans is unclear, and the available observational studies in children are limited. However, the possibility of harm exists. On November 19, 2014, the US Food and Drug Administration (FDA) Science Board, which provides advice to the FDA commissioner, was asked to evaluate whether the emerging data “are sufficient to conclude that the adverse effects noted in juvenile animals are reasonably expected to also occur in developing humans.”1

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

6 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles

Care at the Close of Life: Evidence and Experience
Pain and Opioid-Induced Neurotoxicity Contributing to Fatigue

Care at the Close of Life: Evidence and Experience
Treatment of Pain and Opioid-Induced Neurotoxicity