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Comment & Response |

Surgical Treatment for Drug-Resistant Epilepsy

Juan Gomez-Alonso, MD, PhD1; Paula Bellas-Lamas, MD2
[+] Author Affiliations
1Retired, Vigo, Spain
2Complexo Hospitalario Universitario de Vigo, Vigo, Spain
JAMA. 2015;313(15):1572. doi:10.1001/jama.2015.2883.
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To the Editor Drs Jobst and Cascino1 emphasized the low number of referrals for epilepsy surgery despite the good outcomes obtained in 2 high-quality randomized clinical trials (RCTs) that compared surgical treatment with pharmacotherapy in patients with temporal lobe epilepsy. But in one RCT, recruitment of patients who had experienced treatment failure with only 2 antiepileptic drugs was so problematic that the trial was halted.2 Enrollment was complete in the other RCT of patients who had experienced treatment failure with 6 antiepileptic drugs.3

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April 21, 2015
Barbara C. Jobst, MD; Gregory D. Cascino, MD
1Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
2Mayo Clinic College of Medicine, Rochester, Minnesota
JAMA. 2015;313(15):1572-1573. doi:10.1001/jama.2015.2886.
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