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ARTICLE | December 27, 1919

CUTANEOUS REACTION TO QUININ IN QUININ IDIOSYNCRASY

B. M. EDLAVITCH, M.D.

JAMA. 1919;73(26):1933-1934. doi:10.1001/jama.1919.02610520023012.

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Some individuals are susceptible to the action of certain foreign substances. The urticarial rashes brought on by strawberries, the eczematoid dermatoses due to various proteins or food products, the asthma caused by white of egg, the hay-fever or asthma caused by pollens of plants or by inhalations of animal emanations or derivatives, the skin reaction to tuberculin, and the various symptoms following the use of certain drugs are specific examples of such idiosyncrasies. Symptoms commonly observed in hypersensitive individuals are: (1) urticarial or eczematoid rashes; (2) gastro-intestinal disturbances; (3) those characterized as asthma, or (4) those indicating exaggerated pharmacologic action of the antigenic drug.

Among the drugs to which man manifests this idiosyncrasy is quinin. This fact has long been known.

An attempt to develop a specific skin reaction to quinin was successfully made by Boerner.¹ By applying quinin bisulphate to a skin scarification made on himself and a

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EDLAVITCH BM. CUTANEOUS REACTION TO QUININ IN QUININ IDIOSYNCRASY. JAMA. 1919;73(26):1933-1934. doi:10.1001/jama.1919.02610520023012.

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