JAMA. 1919;73(19):1433-1437. doi:10.1001/jama.1919.02610450029008.
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The important part played by anaphylaxis in the causation of various eruptions has long been recognized. In a paper dealing with drug exanthems in relation to anaphylaxis, Cole1 includes a brief but comprehensive review of the literature of the subject, and defines anaphylaxis as "a state of hypersusceptibility of the organism to foreign substances, which is brought about by the introduction of certain foreign proteins and their cleavage products."

The incubation period of sensitization varies in different species of animals from six to twenty-one days; and is shorter after intravenous than after subcutaneous injection. After an animal has once become sensitized, the hypersusceptibility persists almost indefinitely, and as Rosenau and Anderson2 have demonstrated, may be transmitted from a mother to her offspring.

CAUSE OF ANAPHYLAXIS  Cooke3 summarizes as follows: A foreign protein, not in itself toxic, gains entrance into the circulation for the first time. It stimulates


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