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EXFOLIATIVE DERMATITIS, COMPLICATED WITH CELLULITIS, OBLITERATIVE ARTERITIS AND GANGRENE OF TOES, DUE TO ARSPHENAMIN(?)

Henry A. Jones, M.D.
JAMA. 1919;73(18):1359-1360. doi:10.1001/jama.1919.26120440001014a.
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S. J., colored woman, aged 28, married, was arrested, Oct. 30, 1918, and sent to the house of correction for six months on a charge of lewdness and wantonness. She was a strong, robust young woman without any special organic trouble. Her blood gave a Wassermann test of + + + + by cholesterin and + + + by alcoholic extract of guinea-pig's heart. Specific trouble of any known character was denied. Nov. 15, 1918, she was given 0.3 gm. of arsphenamin intravenously in the left arm, and some of the drug entering into the adjoining tissues set up a marked local inflammation, with contracture of the tendon of the biceps. This condition of contracture called for energetic treatment by massage and mechanotherapeutics, such as carrying a weight in the hand and daily increasing the load to overcome the tendency to contract. In connection with this local infection she had a severe systemic disturbance. The second injection

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