This is the second of a series of articles on the pharmacology, physiology and practical application of the common laxatives and cathartics. The first article appeared October 18.
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Alvarez, W. C.: Is the Purgation of Patients before Operation Justifiable? Surg., Gynec. & Obst. 26: 651 (
Alvarez, W. C., and Taylor, F. B.: Changes in Rhythmicity, Irritability and Tone in the Purged Intestine , J. Pharmacol. & Exper. Therap. 10: 365 (
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Alvarez (J. A. M. A. 65: 388 [
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McPherson, R.: The Routine Use of Cathartics during the Puerperium , Bull. Lying-In Hosp. , New York, 11: 118 (
Hirsch and Wagner, in Krause-Garré: Lehrbuch der Therapic Innerer Krankheiten, 2: 522.
Gee, S. J.: Medical Lectures and Aphorisms , Oxford University Press, 1908;, p. 268.
These may produce constipation by causing stenosis, or else by upsetting the intestinal "gradient" (Alvarez), a lower portion of the intestine having become more irritable than the portion above it.