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October 18, 1919, Vol 73, No. 16 >
ARTICLE | October 18, 1919

THE INFLUENCE OF DESICCATION ON HUMAN NORMAL ISOHEMAGGLUTININS

HOWARD T. KARSNER, M.D.; HERBERT L. KOECKERT, M.D.
JAMA. 1919;73(16):1207-1210. doi:10.1001/jama.1919.02610420035012.
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The practical importance of human normal isohemagglutinins in determining the suitability of prospective donors for the transfusion of blood has been emphasized many times. The quest for an accurate, rapid and convenient method of determining the compatibility of donor and recipient has led to the development of a large number of methods to supersede the older time-consuming methods described in the various textbooks.1 The methods of Epstein and Ottenberg2 and Fishbein,3 designed to accomplish a large number of tests with a small amount of blood, were simplified first by Weil.4 Rous and Turner5 then added the advantage of further blood economy. The timesaving method of Brem6 was improved on by Moss,7 but involved the use of washed corpuscles; this was obviated by Minot's modification,8 which is quite similar to the method of Lee.9 These were followed by the methods of Coca,

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