To the Editor:
—I agree with Dr. Rosenheck's statement (The Journal, July 19, 1919, p. 214) that physicians who administer arsphenamin occasionally encounter a case in which the veins in the cubital space are difficult to locate. I do not, however, agree with his suggestion to select the varicose veins of the legs. Varicose veins, from a pathologic standpoint, are in a state of subacute or chronic inflammation. This explains the frequent occurrence of acute phlebitis in the lower extremities of females after slight or no trauma. The introduction of an irritant drug, such as arsphenamin, into the veins is sufficient to excite an acute exacerbation resulting in thrombosis and complete obliteration. This, perhaps, does not generally follow after the first injection, but will appear in one of the later ones. To improve on this, I have found the dorsal surface of both hands and wrists convenient places to locate