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July 12, 1919, Vol 73, No. 2 >
ARTICLE | July 12, 1919

A METHOD FOR THE PREPARATION OF PROPHYLACTIC AND AUTOGENOUS LIPOVACCINES

E. C. ROSENOW, M.D.; E. OSTERBERG, B.S., Ch.E.
JAMA. 1919;73(2):87-91. doi:10.1001/jama.1919.02610280013004.
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In prophylactic inoculations with a mixed vaccine against influenza and its complications, it was noted that a small percentage of the persons inoculated developed rather severe reactions.1 The possible advantages to be derived by suspending the bacteria in oil, especially when a mixed vaccine is indicated, as first practiced by Le Moignic and Pinoy2 and studied on a large scale by Whitmore and his co-workers in the Army Medical School,3 have been pointed out in a preliminary report. Owing to the slow absorption and the fact that bacterial toxins are lipotropic, larger doses may be given with less local and constitutional reaction than when the bacteria are suspended in salt solution. The formation of antibodies should be more marked andthe resulting immunity more enduring.

The chief difficulty encountered in the preparation of a lipovaccine arises from the fact that the bacteria must be dried, and all methods

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